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KMID : 0377519810060040561
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Chung-Ang Journal of Medicine
1981 Volume.6 No. 4 p.561 ~ p.566
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Morphological Quntitative Study on Endocrine Pancreas - Effects of Pregnancy, Lactation and Suppression of Lactation
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Kim Kyung-Soo
Lee Won-Bok
Rah Bong-Jin
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Abstract
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The hypertrophy of pancreatic islets of pregnant rats is caused by the increased uptake of food due to fetal demand and by the increased hormonal secretions, estrogen and progesterone. These hormones are closely related with the growth of breast, and the maximal growth results from a combination of prolactin and growth hormone in addition to them. Prolactin continues to secrete during lactation after parturition. Expecting the islet changes after parturition in that reason, this experiment is designed to observe the effects of the pregnancy, lactation and suppression of lactation. Those changes are studied quantitatively by calculating the percentage of endocrine tissue, according to the method of Cardell, on sections stained with hematoxylin and eosin. Results obtained are as follows: 1. The islets have normal appearance. But in the full term and lactation groups there are islets, large round or irregular in shape. 2. The percentage of endocrine tissue of the full term is 7.66±3.12 which shows significant increase in comparing with the control. 3. The percentage of endocrine tissue in the group of lactation for 20 days shows 6.86±2.34 which is relatively significant increase (P<.025). 4. In the group of lactation for 40 days the percentage of endocrine tissue shows 7.80±4.19 but it is not significant to compare with the control. 5. in the group of suppressed lactation for 20 days, the percentage is 4.55±1.43 that shows the decrease in comparing with the full term and seems to restore to the control. (P<.025). Above results show not only the hypertrophy of pancreatic islets in pregnancy but do also the same change during lactation, and the possible causes are discussed.
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